People

I am, together with the Center coordinator, the contact person and responsible for budget and the overall scientific progress. I supervise PhD students, mentor postdocs and assistant professors, and look for additional funding. I am also head of the Section for Microbial and Chemical Ecology at Department of Biotechnology and Bioengineering. My science evolves around bacterial ecophysiology and biotechnology with a focus on marine bacterial I am a member of the Research Council for Natural Science.

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My group works at the interface of microbial genomics, ecology, and functional genetics to understand, engineer, and control bacterial systems that relate to medicine, sustainable agriculture, and biotechnology. Our work is largely centered on Pseudomonas species
Our activities in CeMiSt revolves around understanding the role of the genetic and chemical diversity of Pseudomonas species in soils. We are currently developing/applying synthetic biology tools to be able to manipulate secondary metabolite production in different Pseudomonas species, and work with chemists to detect and quantify these molecules.

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My group is interested in developing computational tools, such as antiSMASH, to mine the genomes of microorganisms for the presence of secondary metabolite biosynthetic gene clusters that code for the production of these complex metabolites and use these data to engineer the production of these compounds.
Within CeMiSt, we are mainly involved in adapting and optimizing our tools for the bioinformatics tasks within the center.

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My research is focused on the computational analysis of microorganisms, with a particular focus on how they assemble themselves into microbiomes. We use, and develop, advanced bioinformatic and statistical methods in this endeavor, which we use for analysis of the data generated in the group and by our collaborators. In the context of CeMiSt, I am involved in the analysis of most of the data generated, which includes metataxonomic, metagenomic, metatranscriptomic and metaproteomic data which allows us to profile our systems from all angles. A novel, but major, focus is currently the statistical integration of all -omics data using network theory and machine learning.

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I study and teach microbial natural product chemistry, and am in particular interested in discovery of novel of bioactive compounds and their biosynthetic pathways. The current activities in my research group are focused on genomics driven discovery and engineering of cryptic secondary metabolite biosynthetic pathways in filamentous fungi, as well as chemical ecology and toxicity of natural products from marine bacteria and fish killing microalgae. I’m also involved in activities aiming at commercialization of novel fungal pigments and is a member of the executive board of CeMiSt.

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I have a background within marine microbiology with special interests in molecular microbiology and genome engineering. During my postdoctoral training, I developed molecular tools to manipulate genes in marine proteobacteria and generated a series of scarless deletion mutants to unravel the biosynthetic pathway and the physiological role of secondary metabolites (SMs) in the native producers. My research activity at CeMiSt will be focused on understanding the molecular mode of action of how those SMs affect the physiology of the producer and interactions with other microorganisms in the relevant microbiomes.

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The overarching theme of my research activities is how microbes act and interact in their environment, and how we can investigate and utilize their behavior by analyzing the molecules they comprise and produce. With a special focus on marine environments, I am currently investigating to what extent microbial community members, which are proficient producers of bioactive secondary metabolites, are capable of shaping microbial communities.

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I am the manager of the Metabolomics Core at the Department of Bioengineering and work closely with CeMiSt on the analysis of secondary metabolites found within complex biological systems. I have a background in marine natural products chemistry and metabolomics, and worked on many different marine organisms, producing antibiotics or toxins. This has given me a keen interest in secondary metabolite discovery and understanding the role of these metabolites within the environment. We use the latest techniques and instrumentation in mass spectrometry coupled to chromatography, I am interested producing high quality metabolomics data and using this to investigate metabolites in biological systems.

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My research is focused on (1) understanding the ecological role of ribosomally synthesized and post-translationally modified peptides (RiPPs) in natural and engineered systems, and (2) implementing new LCMS-based metabolomics tools like GNPS molecular networking to help answer the biological questions explored in the center. RiPPs are found in all kingdoms of life and their broader ecological roles are not well understood. Using multi-omics, I aim to investigate the ecological impact of RiPPs through known and new chemistry via the CeMiSt systems. LCMS-based metabolomics provides an unparalleled service for the analysis of complex organic extracts. I am involved in implementing and developing tools on the GNPS platform, providing innovative metabolomics tools that aid in everything from drug discovery to chemical ecology.

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As a coordinator I assist the Center leader in running and coordinating practical, administrative, scientific and social activities in CeMiSt in liaison with the DTU Bioengineering administrative support.
I assist the Center leader and other CeMiSt scientists in arranging meetings and events. Together with the Center leader, I compile material and input for writing of the annual report and other documents. I develop and update the Center webpage, and am responsible for running the Center events, such as workshops, lectures, seminars and conferences. 

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My research bridges molecular biology and computational microbiology to understand microbial genomics and community interactions. I have expertise in nucleic acids extraction from complex environmental matrices, high molecular weight DNA isolation, and quantitative PCR, combined with advanced bioinformatics approaches for analyzing metagenomic datasets and characterizing mobile genetic elements and strain diversity.

In CeMiSt, I apply both wet-lab and computational methods to link genomic potential with secondary metabolite production in microbial communities. My work spans from sample processing and library preparation optimization across sequencing platforms (Illumina, PacBio, Oxford Nanopore) to metagenome assembly, comparative genomics, single-cell omics, and Hi-C-based approaches for resolving genetic element dynamics. I support the center's multi-omics integration through advanced statistical analysis and pipeline development, helping to uncover the ecological roles of secondary metabolites in soil and marine microbiomes

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