People

Leadership and Faculty Members

   

Lone Gram, Professor, Center Leader

https://orcid.org/0000-0002-1076-5723

What I do: I am the leader of the CeMiSt Center. I am, together with the Center coordinator, the contact person and responsible for budget and the overall scientific progress. I supervise PhD students, mentor postdocs and assistant professors, and look for additional funding. I am also head of the Section for Microbial and Chemical Ecology at Department of Biotechnology and Bioengineering. My science evolves around bacterial ecophysiology and biotechnology with a focus on marine bacterial I am a member of the Research Council for Natural Science.

Where to find me: Building 221, Room 140

How to reach me: gram@bio.dtu.dk

 

Ramona Mateiu, Center Coordinator

https://orcid.org/0000-0003-2968-5704

What I do: I am the center coordinator of CeMiSt. My role is to assist the center leader with the daily managing, with focus on effectiveness, implementation, goal achievements and reporting to stakeholders. I keep finances updated, carry out science communication actions through our media channels, organize scientific conferences and promotion events as well as assisting in the process of hiring new researchers. I am also the correspondent anchor at CeMiSt and the link to our host institution, DTU Bioengineering.

Where to find me: Building 221, Room 138

How to reach me: rami@dtu.dk

     
 Eva Sonnenschein, Senior Researcher




https://orcid.org/0000-0001-6959-5100

What I do:
I am a marine microbiologist investigating how microorganisms interact and communicate in beneficial and detrimental ways on a microscopic scale. I study bacteria and microalgae and their interaction pathways from their genes to their environmental effect and distribution in the laboratory and in silico. My aim is to predict how chemical communication controls and is controlled by the environment.

Where to find me: Building 221, Room 152

How to reach me: 
evaso@bio.dtu.dk

   Akos Kovacs, Professor




https://orcid.org/0000-0002-4465-1636

What I do: I study bacterial interaction and evolution, and the underlying phenotypic and genetic changes. My group aims to reveal the ecology of Bacilli, understand their social interactions during biofilm development and adaptation in the presence of other microorganisms, including soil derived bacteria and fungi, in which niche secondary metabolites are expected to have a great impact.

Where to find me: Building 221, Room 158

How to reach me: atkovacs@dtu.dk

     

Charlotte Held Gotfredsen, Associate Professor



https://orcid.org/0000-0002-7386-119X

What I do: I am Head of the NMR Center • DTU, a newly established DTU campus core infrastructure. My research group has special interest in the field of NMR spectroscopy at the interface between chemistry and biology as a tool to acquire structural knowledge and compound identification and tracking. In CeMiSt we will be working and using the NMR and chemistry competences with focus on interdisciplinarity, exploring NMR in the study of secondary metabolites and their evolutionary role.

Where to find me: Building 207, Room 210

How to reach me: chg@kemi.dtu.dk

 

Claus Sternberg, Senior Researcher

 

https://orcid.org/0000-0002-2572-0288

What I do: I have been involved in microbial biofilm research for many years, and have studied online the architecture and physiology of cells growing as biofilms.
Currently, I am heading the bioimaging core at DTU Bioengineering where I participate and assist in optical analysis of biological systems, including bacterial and fungal cells and communities.  

Where to find me: Building 221, Room 262

How to reach me: cst@bio.dtu.dk


     
 

Jens Frisvad, Professor



https://orcid.org/0000-0002-0573-4340

What I do: Biological and chemical diversity of the genera Aspergillus, Penicillium and Talaromyces. Prevention of growth and mycotoxin production, and biotechnological exploitation of filamentous fungi. Key findings: Fungal species are clear-cut classes, are specifically associated to different substrates and produce species specific profiles of secondary metabolites.

Where to find me: Building 221, Room 124

How to reach me: jcf@bio.dtu.dk

     

Lars Jelsbak, Professor MSO


https://orcid.org/0000-0002-5759-9769

What I do: My group works at the interface of microbial genomics, ecology, and functional genetics to understand, engineer, and control bacterial systems that relate to medicine, sustainable agriculture, and biotechnology. Our work is largely centered on Pseudomonas species
Our activities in CeMiSt revolves around understanding the role of the genetic and chemical diversity of Pseudomonas species in soils. We are currently developing/applying synthetic biology tools to be able to manipulate secondary metabolite production in different Pseudomonas species, and work with chemists to detect and quantify these molecules

Where to find me
: Building 221, Room 260

How to reach me
lj@bio.dtu.dk

     
 Ling Ding, Associate Professor


https://orcid.org/0000-0001-8979-3104

What I do: My research interests are listed below.

-Natural product analysis and isolation

-Biosynthetic investigation of unusual secondary metabolites.

Where to find me
: Building 221, Room 122

How to reach melidi@dtu.dk


   Mikael Lenz Strube, Associate Professor


https://orcid.org/0000-0003-0905-5705

What I do
: I work on bioinformatical analysis of metagenomic and metataxonomic data derived from all microbiological niches.

Where to find me: Building 221, Room 148

How to reach memilst@dtu.dk


     
 Mikkel Bentzon-Tilia, Associate Professor



https://orcid.org/0000-0002-7888-9845

What I do: The overarching theme of my research activities is how microbes act and interact in their environment, and how we can investigate and utilize their behavior by analyzing the molecules they comprise and produce. With a special focus on marine environments, I am currently investigating to what extent microbial community members, which are proficient producers of bioactive secondary metabolites, are capable of shaping microbial communities.

Where to find me: Building 221, Room 152

How to reach memibti@bio.dtu.dk


 

Rasmus John Normand Frandsen, Associate Professor


https://orcid.org/0000-0002-3799-6062

What I do
:

• Elucidation of natural biosynthetic pathways in filamentous fungi and insects
• Extensive experience with plant pathogen fungi belonging to the Fusaria genus
• Expert on molecular biology and genome engineering in fungi
• Production of small molecules in (heterologous expression/production)

In connection with the CeMiSt Center, my work will focus on understanding various fungi’s production of small molecules as a response to the continuously changing environment and microbiota in the ecosystem that they naturally inhabit. This work will entail: 1) Construction of fungi with build-in reporter systems that will allow us to visually track the individual cell’s location in a given sample (e.g. apples) and their production of various metabolites. 2) Elucidate the function of the chemical arsenal that the fungi possess, by creating fungi that overproduce or do not produce the given compounds, and then analyze their fitness and impact in the analyzed ecosystem.
My interest spans from the molecular level (DNA, proteins and small molecules) to the entire ecosystem, and both at the minute to minute as well as at the evolutionary timescale.

Where to find me: Building 223, Room 226

How to reach merasf@bio.dtu.dk


     
 Thomas Ostenfeld Larsen, Professor


https://orcid.org/0000-0002-3362-5707

What I do: I study and teach microbial natural product chemistry, and am in particular interested in discovery of novel of bioactive compounds and their biosynthetic pathways. The current activities in my research group are focused on genomics driven discovery and engineering of cryptic secondary metabolite biosynthetic pathways in filamentous fungi, as well as chemical ecology and toxicity of natural products from marine bacteria and fish killing microalgae. I’m also involved in activities aiming at commercialization of novel fungal pigments and is a member of the executive board of CeMiSt.

Where to find me: Building 221, Room 126

How to reach metol@bio.dtu.dk


 

Tilmann Weber, Professor


https://orcid.org/0000-0002-8260-5120

What I do: My group is interested in developing computational tools, such as antiSMASH, to mine the genomes of microorganisms for the presence of secondary metabolite biosynthetic gene clusters that code for the production of these complex metabolites and use these data to engineer the production of these compounds.
Within CeMiSt, we are mainly involved in adapting and optimizing our tools for the bioinformatics tasks within the center.

Where to find me: Building 220, Room 327D

How to reach metiwe@biosustain.dtu.dk


     

Shengda Zhang, Assistant Professor

https://orcid.org/0000-0002-2220-3904

What I do:  I have a background within marine microbiology with special interests in molecular microbiology and genome engineering. During my postdoctoral training, I developed molecular tools to manipulate genes in marine proteobacteria and generated a series of scarless deletion mutants to unravel the biosynthetic pathway and the physiological role of secondary metabolites (SMs) in the native producers. My research activity at CeMiSt will be focused on understanding the molecular mode of action of how those SMs affect the physiology of the producer and interactions with other microorganisms in the relevant microbiomes.

Where to find me: Building 221, Room 148

How to reach me: shez@dtu.dk

 


   Aaron John Christian Andersen, Platform Manager


https://orcid.org/0000-0002-3876-7480

What I do:

As the manager of the Metabolomics Core at the Department of Bioengineering I work closely with CeMiSt to help facilitate the analysis of secondary metabolites found within complex biological systems. With a background in marine natural products chemistry and metabolomics, I have undertaken research on many different marine organisms, from antibiotic producing arctic marine invertebrates to fish killing microalgae with global distributions. These varying biological substrates, as well as their complex and unique molecular profiles, has given me a keen interest in secondary metabolite discovery and understanding the role of these metabolites within the environment. Using the latest techniques and instrumentation in mass spectrometry coupled to chromatography, I am interested producing high quality metabolomics data and using this to investigate metabolites in biological systems

Where to find meBuilding 221,  Room 118


How to reach me: ajca@dtu.dk